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AbstractOne of the most challenging problems in biomedicine and genomics is the identification of disease biomarkers. In this study, proteomics data from seven major cancers were used to construct two weighted protein–protein interaction networks, i.e., one for the normal and another for the cancer conditions. We developed rigorous, yet mathematically simple, methodology based on the degeneracy at –1 eigenvalues to identify structural symmetry or motif structures in network. Utilizing eigenvectors corresponding to degenerate eigenvalues in the weighted adjacency matrix, we identified structural symmetry in underlying weighted protein–protein interaction networks constructed using seven cancer data. Functional assessment of proteins forming these structural symmetry exhibited the property of cancer hallmarks. Survival analysis refined further this protein list proposing BMI, MAPK11, DDIT4, CDKN2A, and FYN as putative multicancer biomarkers. The combined framework of networks and spectral graph theory developed here can be applied to identify symmetrical patterns in other disease networks to predict proteins as potential disease biomarkers.

High symmetry epitaxial quantum dots (QDs) with three or more symmetry planes provide a very promising route for the generation of entangled photons for quantum information applications. The great challenge to fabricate nanoscopic high symmetry QDs is further complicated by the lack of structural characterization techniques able to resolve small symmetry breaking. In this work, we present an approach for identifying and analyzing the signatures of symmetry breaking in the optical spectra of QDs. Exciton complexes in InGaAs/AlGaAs QDs grown along the [111]B crystalline axis in inverted tetrahedral pyramids are studied by polarization resolved photoluminescence spectroscopy combined with lattice temperature dependence, excitation power dependence and temporal photon correlation measurements. By combining such a systematic experimental approach with a simple theoretical approach based on a point-group symmetry analysis of the polarized emission patterns of each exciton complex, we demonstrate that it is possible to achieve a strict and coherent identification of all the observable spectral patterns of numerous exciton complexes and a quantitative determination of the fine structure splittings of their quantum states. This analysis is found to be particularly powerful for selecting QDs with the highest degree of symmetry ( C 3 v and ##IMG## [http://ej.iop.org/images/1367-2630/17/10/103017/njp519062ieqn1.gif] $D_3h$ ) for potential applications of these QDs as polarization entangled photon sources. We exhibit the optical spectra when evolving towards asymmetrical QDs, and show the higher sensitivity of certain exciton complexes to symmetry breaking. ; Funding agencies: Swiss National Science Foundation; Swedish Government Strategic Research Area in Materials Science on Functional Materials at Linkoping University (Faculty Grant SFO-Mat-LiU) [2009-00971]

Abstract
Alphaviruses are spherical, enveloped RNA viruses with two-layered icosahedral architecture. The structures of many alphaviruses have been studied using cryogenic electron microscopy (cryo-EM) reconstructions, which impose icosahedral symmetry on the viral particles. Using cryogenic electron tomography (cryo-ET), we revealed a polarized symmetry defect in the icosahedral lattice of Chikungunya virus (CHIKV) in situ, similar to the late budding particles, suggesting the inherent imperfect symmetry originates from the final pinch-off of assembled virions. We further demonstrated this imperfect symmetry is also present in in vitro purified CHIKV and Mayaro virus, another arthritogenic alphavirus. We employed a subparticle-based single-particle analysis protocol to circumvent the icosahedral imperfection and boosted the resolution of the structure of the CHIKV to ∼3 Å resolution, which revealed detailed molecular interactions between glycoprotein E1–E2 heterodimers in the transmembrane region and multiple lipid-like pocket factors located in a highly conserved hydrophobic pocket. This complementary use of in situ cryo-ET and single-particle cryo-EM approaches provides a more precise structural description of near-icosahedral viruses and valuable insights to guide the development of structure-based antiviral therapies against alphaviruses.

Abstract
In this study we analyzed to what extent partners who share the same household affect each other's exposure to television. With the use of linear structural equation modeling we analyzed data from a large scale representative survey in The Netherlands (n = 697 couples). Results indicate that both men and women influence their partner's exposure to television. When people spend much time watching television, their partners are also likely to spend a lot of time in front of the television. These influences on each other's exposure were of equal magnitude for both men and women. Finally, we found a strong socialization effect of parental viewing in the family of origin.

This article studies the symmetry in reactions of the Andean Community of Nations (CAN) economies to external shocks in order to analyze the group's evolution towards economic integration. The undertaking of a Monetary Union project in South America enhances the usefulness of evaluating shocks within this region according to the Optimal Currency Area Theory. A Structural VAR model with non-recursive contemporaneous restrictions is built for each economy and a correlation analysis is performed. The results evidence that the CAN has evolved positively towards structural convergence.

This article studies the symmetry in reactions of the Andean Community of Nations (CAN) economies to external shocks in order to analyze the group's evolution towards economic integration. The undertaking of a Monetary Union project in South America enhances the usefulness of evaluating shocks within this region according to the Optimal Currency Area Theory. A Structural VAR model with non-recursive contemporaneous restrictions is built for each economy and a correlation analysis is performed. The results evidence that the CAN has evolved positively towards structural convergence.

This article studies the symmetry in reactions of the Andean Community of Nations (CAN) economies to external shocks in order to analyze the group's evolution towards economic integration. The undertaking of a Monetary Union project in South America enhances the usefulness of evaluating shocks within this region according to the Optimal Currency Area Theory. A Structural VAR model with non-recursive contemporaneous restrictions is built for each economy and a correlation analysis is performed. The results evidence that the CAN has evolved positively towards structural convergence.

This article studies the symmetry in reactions of the Andean Community of Nations (CAN) economies to external shocks in order to analyze the group's evolution towards economic integration. The undertaking of a Monetary Union project in South America enhances the usefulness of evaluating shocks within this region according to the Optimal Currency Area Theory. A Structural VAR model with non-recursive contemporaneous restrictions is built for each economy and a correlation analysis is performed. The results evidence that the CAN has evolved positively towards structural convergence.

International audience ; Singularized as it is by a clear axis of symmetry, the novel's dual structure perfectly expresses Phillips' s purpose to suggest contrasts as well as comparisons, differences as well as similitudes. Such a dyadic organization seems to set apart the Afro-American narratives of the first part and the British accounts of the second part, but, in fact, Phillips weaves together the various narrative threads using an aesthetics of fragmentation which shows simultaneously the common fractures of these suffering testimonies and the impossible coherence of so many narratives of trauma. By thus highlighting the shared features of the black accounts and the white accounts, Phillips demonstrates his deterrnination to deconstruct ail dichotomies, be they poetic or political.

International audience ; Singularized as it is by a clear axis of symmetry, the novel's dual structure perfectly expresses Phillips' s purpose to suggest contrasts as well as comparisons, differences as well as similitudes. Such a dyadic organization seems to set apart the Afro-American narratives of the first part and the British accounts of the second part, but, in fact, Phillips weaves together the various narrative threads using an aesthetics of fragmentation which shows simultaneously the common fractures of these suffering testimonies and the impossible coherence of so many narratives of trauma. By thus highlighting the shared features of the black accounts and the white accounts, Phillips demonstrates his deterrnination to deconstruct ail dichotomies, be they poetic or political.

International audience ; Singularized as it is by a clear axis of symmetry, the novel's dual structure perfectly expresses Phillips' s purpose to suggest contrasts as well as comparisons, differences as well as similitudes. Such a dyadic organization seems to set apart the Afro-American narratives of the first part and the British accounts of the second part, but, in fact, Phillips weaves together the various narrative threads using an aesthetics of fragmentation which shows simultaneously the common fractures of these suffering testimonies and the impossible coherence of so many narratives of trauma. By thus highlighting the shared features of the black accounts and the white accounts, Phillips demonstrates his deterrnination to deconstruct ail dichotomies, be they poetic or political.

Purpose
The purpose of this paper is to provide scholars with a robust, easy-to-follow structural model for crafting compelling academic publications. Recognizing the diversity of research methodologies and genres, the paper proposes the symmetry of specificity framework as a guide to maintaining coherence, depth and relevance across different sections of an academic paper.


Design/methodology/approach
This paper presents a theoretical framework – "symmetry of specificity" – through an iterative approach inspired by supervision and examination of theses, writing and reviewing research papers and editorial work. The framework builds upon the established IMRAD model and uses the concept of symmetry to explain the structural elements of academic publications. Its unique contribution lies in elucidating the two-dimensional funneling process that takes place within academic writing, and providing a nuanced understanding of how to maintain balance between different sections.


Findings
The symmetry of specificity framework introduces a novel perspective on academic writing, emphasizing the concept of "symmetry in specificity". It shows how maintaining a balance in detail and focus across different sections of a research paper can significantly enhance its coherence and relevance. By elucidating the interaction between theory and data in research writing, it provides valuable insights into the nuances of crafting a compelling academic paper.


Research limitations/implications
While the proposed symmetry of specificity framework may not be universally applicable across all types of research, it provides a solid foundation for the development of alternate structures tailored to specific research paradigms. There is ample opportunity for future research to explore adaptations of this model for various types of academic writing, offering a fresh perspective on structuring academic publications and potentially sparking new discussions and innovations in this realm.


Practical implications
This framework can aid both novice and experienced scholars in structuring their research papers effectively. By offering a conceptual roadmap, it guides the writer through the complex process of academic writing, from crafting the methodology and analysis sections to articulating compelling conclusions. Thus, it serves as a useful tool in enhancing the quality and impact of research communication.


Originality/value
This paper presents a unique approach to structuring academic publications that goes beyond the conventional IMRAD model. By offering a theory-based structural model, it contributes to an underexplored area in academic writing and opens up new avenues for pedagogy and practice in research communication.